Evaluation of relationship between BMI with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome

نویسندگان

  • Esmat Aghadavod 1Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran
  • Hakimeh Mollae Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Nouri Women Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
چکیده مقاله:

Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin action and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. The aim of this study was to evaluate the effect of BMI on vitamin D levels in follicular fluid and vitamin D receptor (VDR) expression levels in granulosa cells. MaterialsAndMethods This prospective case-control cross-sectional study was conducted on 80 women with average ages of 20-35 years referred for in-vitro fertilization. Patients were divided into four groups and serum levels of testosterone and insulin resistance (HOMA-IR) were evaluated at the puncture time; also vitamin D levels of follicular fluid were evaluated. VDR gene expression was assayed by quantified-PCR technique. Results Vitamin D levels of follicular fluid decreased in PCOS patients compared with non-PCOS. Also over-weight individuals had lower vitamin D levels compared with normal- weight patients. Vitamin D levels of follicular fluid were highly correlated with BMI (r = - 0.51, P < 0.001). HOMA-IR values were significantly higher in women of PCOS/Overweight and PCOS/Normal weight than in women of non-PCOS/Normal weight (p < 0.001). The gene expression data of VDR in granulosa cells were significantly lower in the PCOS/Overweight group compared with the non-PCOS/Normal weight (P < 0.001). Conclusion Our findings indicate that there are significant differences in the VDR gene expression in granulosa cells and vitamin D of follicular fluid in PCOS/overweight patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of Relationship between Body Mass Index with Vitamin D Receptor Gene Expression and Vitamin D Levels of Follicular Fluid in Overweight Patients with Polycystic Ovary Syndrome

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrine disorder associated with reproductive disorders and metabolic dysfunctions including insulin resistance. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. T...

متن کامل

The relationship between Polycystic ovary syndrome and vitamin D levels

OBJECTIVE The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS). MATERIALS AND METHODS Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m2) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m2) women with PCOS and 56 nor...

متن کامل

Pnm-29: Effects of Vitamin D Supplementation in Reproductive Function of Women with Polycystic Ovary Syndrome

Background Vitamin D deficiency is common in women with PCOS. Vitamin D is thought to influence the development of PCOS through gene transcription, and hormonal modulation influences insulin metabolism and fertility regulation. Therefore, the aim of this review article is to study the effects of vitamin D supplementation in reproductive function of PCOS women. MaterialsAndMethods This review ar...

متن کامل

Evaluation of the relationship between serum vitamin D levels and disease recurrence in patients with ulcerative colitis

Background: one of the growing diseases in the world that affects patient life quality is Inflammatory bowel disease (IBD), including ulcerative colitis (UC). Many environmental factors, including nutritional deficiencies, may influence the development of the disease. This study aims to evaluate the role of the level of vitamin D in UC recurrence. Methods: We performed this cross-sectional stu...

متن کامل

Vitamin D deficiency in women with polycystic ovary syndrome

OBJECTIVE TO INVESTIGATE: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. METHODS We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 11  شماره 2

صفحات  105- 111

تاریخ انتشار 2017-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023